Pancreatic surgery is associated with high rate of postoperative complications

•Pancreatic surgery is associated with high rate of postoperative complications1, 2.

•Pancreatic cancer, a leading cause to pancreatic surgeries, has more than doubled from 1990 to 20173.

•Its incidence continues to increase as the population ages and the prevalence of obesity and diabetes, increase.

•Pancreatic operations are an important and growing field of surgery worldwide4

•Intraoperatively derived fluid from the peripancreatic environment may cause complications5, 6, 7

•At present, there are no reliable ways to indicate or visualize pancreatic fluid leakage during pancreatic surgery

•Intraoperative detection of pancreatic fluid leakage may affect reducing complications6


1.Donahue, T.R. & Reber, H.A. Surgical management of pancreatic cancer–pancreaticoduodenectomy. Semin Oncol 42, 98-109 (2015).

2.Parikh, P.Y. & Lillemoe, K.D. Surgical management of pancreatic cancer–distal pancreatectomy. Semin Oncol 42, 110-122 (2015).

3.GBD 2017 Pancreatic Cancer Collaborators. The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2019 Dec;4(12):934-947.

4. AminiN et al,. Trends in Hospital Volume and Failure to Rescue for Pancreatic Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2015;19(9):1581-92. Reuver, P.R., Gundara, J., Hugh, T.J., Samra, J.S. & Mittal, A. Intra-operative amylase in peri-pancreatic fluid independently predicts for pancreatic fistula post pancreaticoduodectomy. HPB (Oxford) 18, 608-614 (2016).

6.Nahm, C.B., et al. Intra-Operative Amylase Concentration in Peri-Pancreatic Fluid Predicts Pancreatic Fistula After Distal Pancreatectomy. J Gastrointest Surg 21, 1031-1037 (2017).

7.Wang, W., et al. Has the pancreatic fistula already occurred in the operation? An intraoperative predictive factor of clinical relevant-postoperative pancreatic fistula after the distal pancreatectomy. Surg Open Sci 1, 38-42 (2019).