Scientific evidence

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Pre-clinical Research

Pre-clinical Research

Publication titleAuthorsJournalAnimal modelPublication date
Chemoembolization of lung metastases–pharmacokinetic behaviour of carboplatin in a rat model (concerns DSM)Pohlen U, Rieger H, Meyer BT, Loddenkemper C, Buhr HJ, Heitland P, Koester HD, Schneider PAnticancer ResRat2007
Synergistic antitumor effects of transarterial viroembolization for multifocal hepatocellular carcinoma in rats (concerns EmboCept)Altomonte J, Braren R, Schulz S, Marozin S, Rummeny EJ, Schmid RM, Ebert OHepatologyRat2008
Hepatic arterial infusion (HAI) with PEGylated liposomes containing 5-FU improves tumor control of liver metastases in a rat model (concerns Spherex)Pohlen U, Buhr HJ, Berger G, Ritz J, Holmer CInvest New DrugsRat2011
Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases: a study in CC-531 liver tumor-bearing WAG RIJ rats (concerns DSM)Pohlen U, Buhr HJ, Berger GAnticancer ResRat2011
Hepatic arterial infusion in the treatment of liver metastases with PEG liposomes in combination with degradable starch microspheres (DSM) increases tumor 5-FU concentration (concerns DSM)Pohlen U, Reszka R, Buhr HJ, Berger GAnticancer ResRat2012
Temporary arterial embolization of liver parenchyma with degradable starch microspheres (EmboCept®S) in a swine model (concerns EmboCept S)Pieper C, Meyer C, Vollmar B, Hauenstein K, Schild HH, Wilhelm KECardiovasc Intervent RadiolSwine2015
In vitro study of physical properties of various embolization particles regarding morphology before, during and after catheter passage (concerns EmboCept)Paprottka KJ, Waggershauser T, Rübenthaler J, Paprottka FJ, Clevert DA, Reiser MF, Paprottka PMClin Hemorheol MicrocircIn vitro2016
Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model (concerns DSM)Qian J, Oppermann E, Tran A, Imlau U, Qian K, Vogl TJWorld J GastroenterolRat2016
Study on the effect of chemoembolization combined with microwave ablation for the treatment of hepatocellular carcinoma in rats (concerns EmboCept)Vogl TJ, Qian J, Tran A, Oppermann E, Naguib NN, Kurkusuz H, Nour-Eldin NA, Bechstein WODiagn Interv RadiolRat2017
Hepatic arterial infusion of irinotecan and EmboCept® S results in high tumor concentration of SN-38 in a rat model of colorectal liver metastases (concerns EmboCept S)Kauffels A, Kitzmüller M, Gruber A, Nowack H, Bohnenberger H, Spitzner M, Kuthning A, Sprenger T, Czejka M, Ghadimi M, Sperling JClin Exp MetastasisRat2019
Intra-arterial EmboCept S® and DC Bead® effectively inhibit tumor growth of colorectal rat liver metastases (concerns EmboCept S)Ziemann C, Roller J, Malter MM, Keller K, Kollmar O, Glanemann M, Menger MD, Sperling JBMC CancerRat2019
Toward Transpulmonary Chemoembolization with Degradable Starch Microspheres: Systematic Analysis of Local and Systemic Effects in a Porcine Model. (concerns EmboCept S)Barabasch A, von Stillfried S, Kuhl CK, Heinzel A, Sander A, Isfort PCardiovasc Intervent RadiolSwine2019
Clinical Research

Clinical Research

Publication titleAuthorsJournalPatientsPublication date
Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy (concerns EmboCept)Vogl TJ, Schwarz W, Eichler K, Hochmuth K, Hammerstingl R, Jacob U, Scheller A, Zangos S, Heller MJ Cancer Res Clin Oncol242006
Transpulmonary chemoembolization (TPCE) as a treatment for unresectable lung metastases (concerns Spherex)Vogl TJ, Lehnert T, Zangos S, Eichler K, Hammerstingl R, Korkusuz H, Lindemayr SEur Radiol522008
Repetitive transarterial chemoembolization (TACE) of liver metastases from renal cell carcinoma: local control and survival results (concerns EmboCept)Nabil M, Gruber T, Yakoub D, Ackermann H, Zangos S, Vogl TJEur Radiol222008
Transarterielle Chemoperfusion und -embolisation thorakaler Neoplasmen mittels C-Arm CT [german] (concerns EmboCept)Vogl TJ, Naguib NN, Nour-Eldin NA, Lehnert T, Mbalisike ERadiologe222009
Repeated transarterial chemoembolization in the treatment of liver metastases of colorectal cancer: prospective study (concerns EmboCept)Vogl TJ, Gruber T, Balzer JO, Eichler K, Hammerstingl R, Zangos SRadiology4632009
Liver metastases of neuroendocrine tumors: treatment with hepatic transarterial chemotherapy using two therapeutic protocols (concerns EmboCept)Vogl TJ, Gruber T, Naguib NN, Hammerstingl R, Nour-Eldin NAAJR Am J Roentgenol482009
Transarterial chemoembolization (TACE) with mitomycin C and gemcitabine for liver metastases in breast cancer (concerns EmboCept)Vogl TJ, Naguib NN, Nour-Eldin NA, Eichler K, Zangos S, Gruber-Rouh TEur Radiol2082009
Liver metastases of pancreatic cancer: role of repetitive transarterial chemoembolization (TACE) on tumor response and survival (concerns EmboCept)Azizi A, Naguib NN, Mbalisike E, Farshid P, Emami AH, Vogl TJPancreas322011
Repeated chemoembolization followed by laser-induced thermotherapy for liver metastasis of breast cancer (concerns EmboCept)Vogl TJ, Naguib NN, Nour-Eldin NA, Mack GM, Zangos S, Abskharon JE, Jost AAJR Am J Roentgenol1612011
Repeated transarterial chemoembolisation using different chemotherapeutic drug combinations followed by MR-guided laser-induced thermotherapy in patients with liver metastases of colorectal carcinoma (concerns EmboCept)Vogl TJ, Jost A, Nour-Eldin NA, Mack MG, Zangos S, Naguib NNBr J Cancer2242012
Initial experience with repetitive transarterial chemoembolization (TACE) as a third line treatment of ovarian cancer metastasis to the liver: indications, outcomes and role in patient’s management (concerns EmboCept)Vogl TJ, Naguib NN, Lehnert T, Nour-Eldin NA, Eichler K, Zangos S, Gruber-Rouh TGynecol Oncol652012
Degradable starch microspheres transarterial chemoembolisation (DSM-TACE) of HCC: Dynamic Contrast-Enhanced Ultrasonography (DCE-US) based evaluation of therapeutic efficacy using a novel perfusion software (concerns EmboCept S)Wiggermann P, Heibl M, Niessen C, Müller-Wille R, Gössmann H, Uller W, Poschenrieder F, Schreyer AG, Wohlgemuth WA, Stroszcynski CClin Hemorheol Microcirc152012
Transarterial chemoembolisation (TACE) with gemcitabine: Phase II study in patients with liver metastases of breast cancer (concerns EmboCept)Eichler K, Jakobi S, Guber-Rouh T, Hammerstingl R, Vogl TJ, Zangos SEur J Radiol432013
Repetitive chemoembolization of hypovascular liver metastases from the most common primary sites (concerns EmboCept)Farshid P, Darvishi A, Naguib NN, Bazrafshan B, Paul J, Mbalisike E, Vogl TJFuture Oncol1902013
Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: Long-term results over a 10-year period (concerns EmboCept)Gruber-Rouh T, Naguib NN, Eichler K, Ackermann H, Zangos S, Trojan JInt J Cancer5642013
Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: A feasibility study (concerns EmboCept S)Heibl M, Jung EM, Beyer L, Wohlgemuth WA, Stroszcynski C, Wiggermann PClin Hemorheol Microcirc182013
Repetitive transarterial chemoembolization (TACE) of liver metastases from gastric cancer: local control and survival results (concerns EmboCept)Vogl TJ, Gruber-Rouh T, Eichler K, Nour-Eldin na, Trojan J, Zangos S, Naguib NNEur J Radiol562013
Dynamic evaluation and quantification of microvascularization during degradable starch microspheres transarterial Chemoembolisation (DSM-TACE) of HCC lesions using contrast enhanced ultrasound (CEUS): a feasibility study (concerns EmboCept S)Wiggermann P, Wohlgemuth WA, Heibl M, Vasilj A, Loss M, Schreyer AG, Stroszcynski C, Jung EMClin Hemorheol Microcirc62013
Feasibility of temporary protective embolization of normal liver tissue using degradable starch microspheres during radioembolization of liver tumours (concerns EmboCept S)Meyer C, Pieper CC, Ezziddin S, Wilhelm KE, Schild HH, Ahmadzadehfar HEur J Nucl Med Mol Imaging542013
Degradable starch microspheres versus ethiodol and doxorubicin in transarterial chemoembolization of hepatocellular carcinoma (concerns EmboCept)Niessen A, Unterpaintner E, Goessmann H, Schlitt HJ, Mueller-Schilling M, Wohlgemuth WAJ Vasc Interv Radiol692013
Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres transcatheter arterial chemo-embolization (concerns EmboCept S)Orlacchio A, Chegai F, Merolla S, Francioso S, Del Guidice C, Angelico M, Tisone G, Simonetti GWorld J Hepatol82015
Transarterial chemoembolization with degradable starch microspheres (DSM-TACE): an alternative option for advanced HCC patients? Preliminary results (concerns EmboCept)Iezzi R, Pompili M, Nestola M, Siciliano M, Annicchiarico E, Zocco MA, Rinninella E, Posa A, Anonuccio GE, Gasbarrini A, Lorenzo B, Hepatocatt Study GroupEur Rev Med Pharmacol Sci62016
Impact of Different Embolic Agents for Transarterial Chemoembolization (TACE) Procedures on Systemic Vascular Endothelial Growth Factor (VEGF) Levels (concerns EmboCept S)Schicho A, Hellerbrand C, Krüger K, Beyer LP, Wohlgemuth W, Niessen C, Hohenstein E, Stroszcynski C, Pereira PL, Wiggermann PJ Clin Transl Hepatol222016
Degradable Starch Microspheres Transcatheter Arterial Chemoembolization (DSM-TACE) in Intrahepatic Cholangiocellular Carcinoma (ICC): Results from a National Multi-Center Study on Safety and Efficacy (concerns EmboCept S)Schicho A, Pereira PL, Pützler M, Michalik K, Albrecht T, Nolte-Ernsting C, Strosczynski C, Wiggermann PMed Sci Monit72017
Transradial versus Transfemoral Access for Hepatic Chemoembolization: Intrapatient Prospective Single-Center Study (concerns DSM)Iezzi R, Pompili M, Posa A, Annicchiarico E, Garcovich M, Merlino B, Rodolfino E, Di Noia V, Basso M, Cassano A, Barone C, Gasbarrini A, Manfredi R, Colosimo CJ Vasc Interv Radiol422017
Transarterial chemoembolization (TACE) with degradable starch microspheres (DSM) in hepatocellular carcinoma (HCC) (concerns EmboCept)Schicho A, Pereira PL, Haimerl M, Niessen C, Michalik K, Beyer LP, Stroszcynski C, Wiggermann POncotarget502017
Transarterial chemoembolization in pancreatic adenocarcinoma with liver metastases (concerns EmboCept)Vogl TJ, Mohamed SA, Albrecht MH, Gruber-Rouh T, Lin H, Nour-Eldin NA, Bednarova I, Naguib NN, Panahi BPancreatology1122017
Safety and efficacy of transarterial chemoembolization with degradable starch microspheres (DSM-TACE) in the treatment of secondary liver malignancies (concerns EmboCept S)Schicho A, Pereira PL, Michalik K, Beyer LP, Stroszcynski C, Wiggermann POnco Targets Ther202018
Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for hepatocellular carcinoma: comparative study (concerns EmboCept S)Gruber-Rouh T, Schmitt C, Naguib NN, Nour-Eldin NA, Eichler K, Beeres M, Vogl TJBMC Cancer992018
Survival of patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases undergoing conventional lipiodol-based transarterial chemo-embolization (cTACE) palliatively versus neoadjuvantly prior to percutaneous thermal ablation (concerns EmboCept)Vogl TJ, Lahrsow M, Albrecht MH, Hammerstingl R, Thomson ZM, Gruber-Rouh TEur J Radiol4522018
Transarterial Chemoembolization (TACE) Using Mitomycin with or without Irinotecan for Hepatocellular Carcinoma in European Patients (concerns EmboCept S)Gruber-Rouh T, Kamal A, Eichler K, Naguib NN, Beeres M, Langenbach M, Vogl TJOncol Res Treat282018
Repeated Transarterial Chemoembolization with Degradable Starch Microspheres (DSM-TACE) of Unresectable Hepatocellular Carcinoma: A Prospective Pilot Study (concerns DSM)Orlacchio A, Chegai F, Francioso S, Merolla S, Monti S, Angelico M, Tisone G, Mannelli LCurr Med Imaging Rev242018
TACE with degradable starch microspheres (DSM-TACE) as second-line treatment in HCC patients dismissing or ineligible for sorafenib (concerns EmboCept)Iezzi R, Pompili M, Rinninella E, Annicchiarico E, Garcovich M, Cerrito L, Ponziani F, De Gaetano A, Siciliano M, Basso M, Zocco MA, Rapaccini G, Posa A, Carchesio F, Biolato M, Giuliante F, Gasbarrini A, Manfredi R; HepatoCatt Study GroupEur Radiol402018
Transvenous pulmonary chemoembolization (TPCE) for palliative or neoadjuvant treatment of lung metastases (concerns EmboCept)Vogl TJ, Mekkawy AIA, Thabet DB, El-Sharkaway M, Kamel HM, Albrecht MH, Naguib NNN, Hassan AEur Radiol1432018
Hepatic arterial therapy with oxaliplatin and systemic capecitabine for patients with liver metastases from breast cancer (concerns EmboCept S)Lindgaard SC, Brinch CM, Jensen BK, Nørgaard HH, Hermann KL, Theile SBreast522019
Intrahepatic Oxaliplatin and Systemic 5-FU +/– Cetuximab in Chemo-Naïve Patients with Liver Metastases from Colorectal Cancer (concerns EmboCept S)Larsen FO, Jensen BV, Norgaard HH, Hermann HK, Larsen PN, Markussen A, Hogdall E, Nielsen DOncology452018
Monitoring Liver Function of Patients Undergoing Transarterial Chemoembolization (TACE) by a 13C Breath Test (LiMAx) (concerns EmboCept)Barzakova ES, Schulze-Hagen M, Zimmermann M, Lurje G, Bednarsch J, Pedersoli F, Isfort P, Kuhl C, Bruners PCardiobasc Intervent Rediol402019
Sequential dual‑phase cone‑beam CT is able to intra‑procedurally predict the one‑month treatment outcome of multi‑focal HCC, in course of degradable starch microsphere TACE (concerns EmboCept S)Lucatelli P, De Rubeis G, Basilico F, Corradini LC, Corona M, Bezzi M, Catalano CLa radiologia medica242019
Degradable starch microspheres transarterial chemoembolization (DSMs‑TACE) in patients with unresectable hepatocellular carcinoma (HCC): long‑term results from a single‑center 137‑patient cohort prospective study (concerns DSM)Orlacchio A, Chegai F, Roma S, Merolla S, Bosa A, Francioso SLa radiologia medica1372019
Chemoembolization with Degradable Starch Microspheres for Treatment of Patients with Primary or Recurrent Unresectable, Locally Advanced Intrahepatic Cholangiocarcinoma: A Pilot Study (concerns EmboCept S)Goerg F, Zimmermann M, Bruners P, Neumann U, Luedde T, Kuhl CCardiovasc Intervent Radiol212019
Transarterial Chemoembolisation (TACE) with Degradable Starch Microspheres (DSM) and Anthracycline in Patients with Locally Extensive Hepatocellular Carcinoma (HCC): Safety and Efficacy (concerns EmboCept S)Gross A, Albrecht TCardiovasc Intervent Radiol372019
Diffusion-Weighted MR Imaging of Primary and Secondary Lung Cancer: Predictive Value for Response to Transpulmonary Chemoembolization and Transarterial Chemoperfusion (concerns EmboCept)Vogl TJ, Hoppe AT, Gruber-Rouh T, Basten L, Dewes P, Hammerstingl RM, Balaban Ü, Mastrodicasa D, Thompson ZM, Albrecht MHJ Vasc Interv Radiol312019
DSM-TACE of HCC: Evaluation of Tumor Response in Patients Ineligible for Other Systemic or Loco-Regional Therapies (concerns EmboCept S)Haubold J, Reinboldt MP, Wetter A, Li Y, Ludwig JM, Lange C, Wedemeyer H, Schotten, C, Umutlu L, Theysohn JRoFo282020
Trans-arterial chemoembolization with degradable starch microspheres (DSM-TACE) versus selective internal radiation therapy (SIRT) in multifocal hepatocellular carcinoma (concerns EmboCept S)Auer TA, Jonczyk M, Collettini F, Marth A, Wieners G, Hamm B and Gebauer BActa Radiologica362020
Transarterial chemoembolization of colorectal cancer liver metastasis: improved tumor response by DSM-TACE versus conventional TACE, a prospective, randomized, single-center trial (concerns EmboCept S)Vogl TJ, Marko C, Langenbach MC, Naguib NN, Filmann N, Hammerstingl R, Gruber-Rouh TEur. Radiol.502021
Safety and Efficacy of Degradable Starch Microspheres Transcatheter Arterial Chemoembolization (DSM-TACE) in the Downstaging of Intermediate-Stage Hepatocellular Carcinoma (HCC) in Patients With a Child-Pugh Score of 8-9 (concerns EmboCept S)Minici R, Ammendola M, Manti F, Siciliano MA, Minici M, Komaei I, Currò G, Laganà DFront Pharmacol502021
Evaluation of two different transarterial chemoembolization protocols using Lipiodol and degradable starch microspheres in therapy of hepatocellular carcinoma: a prospective trial (concerns EmboCept S)Vogl TJ, Langenbach MC, Hammerstingl R, Albrecht MH, Chatterjee AR, Gruber-Rouh THep. Int.612021
European Multicenter Study on Degradable Starch Microsphere TACE: The Digestible Way to Conquer HCC in Patients with High Tumor Burden (concerns EmboCept S)Ludwig J.M., Iezzi R., Theysohn J.M., Albrecht T., Posa A. and Gross A.Cancers1212021